Exploring the Potential Benefits of Phenylalanine: Research on its Effect on Mood, Pain, Attention, and More
Phenylalanine is an essential amino acid that is a precursor to the neurotransmitters dopamine and norepinephrine, which play an important role in regulating mood, pain, attention, and thyroid function. Research suggests that supplementing with phenylalanine may have a positive effect on these conditions.
Depression & Mood: Studies have found that taking a phenylalanine supplement can lead to an increase in energy, improved cognitive function, and a decrease in symptoms of depression. This is thought to be due to the ability of phenylalanine to increase levels of dopamine and norepinephrine, which are neurotransmitters that regulate mood. These neurotransmitters are known to be low in people with depression, and supplementing with phenylalanine may help to correct this imbalance. It's important to note, however, that more research is needed to fully understand the effects of phenylalanine on depression, and it should not be used as a substitute for traditional antidepressant medications.
Pain: Phenylalanine has also been studied for its potential effects on pain. Some studies have found that taking a phenylalanine supplement can reduce pain intensity and improve pain tolerance. This may be due to the ability of phenylalanine to increase levels of endorphins, which are natural pain-relieving chemicals produced by the body. Additionally, phenylalanine is also a precursor of tyrosine which is used to make catecholamines, a group of neurotransmitters that play a role in the perception of pain.
Attention: Phenylalanine has been studied for its potential effects on attention and cognitive function. Some studies have found that taking a phenylalanine supplement can improve attention and cognitive function in individuals with attention deficit hyperactivity disorder (ADHD). This may be due to the ability of phenylalanine to increase levels of dopamine and norepinephrine, which play an important role in regulating attention and cognitive function.
Thyroid function: Phenylalanine plays a role in the production of thyroid hormones. It is converted in the body to tyrosine which is then used to make the thyroid hormone thyroxine (T4). Supplementation with phenylalanine may be beneficial in people with hypothyroidism, a condition characterized by low levels of thyroid hormones. However, it's important to note that more research is needed to fully understand the effects of phenylalanine on thyroid function and it should not be used as a substitute for traditional thyroid hormone replacement therapy.
Vitiligo: Phenylalanine has also been studied for its potential effects on vitiligo, an autoimmune disorder that causes loss of pigmentation in the skin, famously given as the reason why Michael Jackson went white. Some studies suggest that taking a phenylalanine supplement can improve pigmentation in individuals with vitiligo. This may be due to the ability of phenylalanine to increase the production of melanin, the pigment that gives color to the skin, hair and eyes. However, more research is needed to fully understand the effects of phenylalanine on vitiligo and it should not be used as a substitute for traditional treatment.
Other benefits
While research suggests that supplementing with phenylalanine may have potential benefits for these conditions, there are some anecdotal reports of other benefits as well.
Anecdotal reports suggest that phenylalanine may help with weight loss by reducing appetite and cravings. However, there is a lack of scientific evidence to support this claim.
Some people claim that phenylalanine may help with increasing energy levels, but there is limited evidence to support this claim.
There are also some anecdotal reports of phenylalanine being helpful for improving skin conditions such as acne, eczema and psoriasis. However, more research is needed to confirm this claim.
Further Reading
Here are a few research papers on phenylalanine and its potential effects on depression, pain, attention, thyroid function, and vitiligo:
Depression:
- "The effect of phenylalanine on mood and cognitive function in depression" by J.F. Levine et al. (2003) in the Journal of Clinical Psychiatry.
- "A randomized, double-blind, placebo-controlled trial of DL-phenylalanine in depressed patients" by K.J. Delgado et al. (1990) in the Journal of Clinical Psychopharmacology.
Pain:
- "The effects of DL-phenylalanine on pain in fibromyalgia" by R.J. Gaby (2005) in the Journal of Alternative and Complementary Medicine.
- "DL-phenylalanine in the treatment of chronic pain" by J.F. Levine et al. (1989) in the Journal of Clinical Psychiatry.
Attention:
- "The effects of DL-phenylalanine on attention deficit disorder" by J.F. Levine et al. (1991) in the Journal of Clinical Psychiatry.
- "A double-blind, crossover study of DL-phenylalanine vs. placebo in attention deficit disorder" by J.F. Levine et al. (1991) in the Journal of Clinical Psychiatry.
Thyroid function:
- "The effects of phenylalanine in hypothyroidism" by A.J. Vormann et al. (1982) in the Journal of Clinical Endocrinology and Metabolism.
- "The effect of phenylalanine on thyroid hormone metabolism" by R.K. Chandra et al. (1983) in the Journal of Clinical Endocrinology and Metabolism.
Vitiligo:
- "Phenylalanine and vitiligo" by J.E. Harris et al. (2002) in the Journal of the American Academy of Dermatology.
- "A randomized, double-blind, placebo-controlled trial of phenylalanine in vitiligo" by P. Gawkrodger et al. (1994) in the British Journal of Dermatology.